Bringing home a new puppy is a joyful whirlwind of play, snuggles, and training. But one of your very first responsibilities is protecting their fragile immune system. Diseases like Parvovirus and Distemper are still very real threats in 2025, but they are entirely preventable with a proper vaccination schedule.
If you're wondering "How much will puppy shots cost?" or "Which vaccines does my dog really need?", you'e in the right place. This guide breaks down the essential 2025 vaccination schedule, current costs, and safety tips to keep your new best friend healthy for years to come.
Core vs. Non-Core Vaccines: What's the Difference?
Not all vaccines are created equal. The veterinary community divides dog vaccines into two categories: Core (mandatory for all dogs) and Non-Core (optional based on lifestyle).
💉 Core Vaccines (Essential)
These prevent diseases that are widespread, highly contagious, and potentially fatal. Every puppy, regardless of where they live, needs these.
- Rabies: Fatal viral disease attacking the nervous system. Required by law in most US states.
- Distemper: Severe airborne virus attacking respiratory/nervous systems.
- Parvovirus ("Parvo"): Highly contagious, often deadly virus affecting the intestines.
- Adenovirus: Causes infectious hepatitis.
Note: Distemper, Parvo, and Adenovirus are often combined into a single shot called DHPP or DA2PP.
🛡️ Non-Core Vaccines (Lifestyle)
These are recommended based on your location and your dog's activities (boarding, hiking, dog parks).
- Bordetella: "Kennel Cough." Essential for daycare, boarding, or grooming.
- Lyme Disease: Critical if you live in tick-heavy areas (Northeast/Midwest).
- Leptospirosis: bacterial infection from wildlife urine/puddles.
- Canine Influenza: Dog flu, recommended for social dogs.
The Puppy Vaccination Schedule (2025)
Puppies receive immunity from their mother's milk, but this fades between 6-8 weeks. That's when vaccination must start to take over.
6 to 8 Weeks
- Core: DHPP (1st round)
- Non-Core: Bordetella (optional)
10 to 12 Weeks
- Core: DHPP (2nd round)
- Non-Core: Leptospirosis, Lyme, Canine Influenza (1st rounds if needed)
16 to 18 Weeks
- Core: DHPP (3rd round), Rabies (1st shot)
- Non-Core: Leptospirosis, Lyme, Influenza (2nd rounds)
12 to 16 Months
- Boosters: DHPP, Rabies, and all annual non-core vaccines.
How Much Do Puppy Vaccinations Cost in 2025?
Veterinary costs have risen locally and nationally. In 2025, you can expect to spend between $100 - $350 for a complete first-year vaccination series, depending on your location (urban vets cost more) and lifestyle choices.
| Item | Estimated Cost (Per Shot) |
|---|---|
| Examination Fee | $40 - $80 (per visit) |
| DHPP (Core) | $25 - $50 |
| Rabies (Core) | $20 - $40 |
| Bordetella | $30 - $55 |
| Lyme / Lepto | $35 - $60 |
| Low-Cost Clinic Pkg | $75 - $150 (Total Series) |
Safety & Side Effects
Vaccines stimulate the immune system, so mild reactions are normal. Serious reactions are extremely rare but possible.
Normal Side Effects (Lasts 12-24 hours)
- Sleepiness or lethargy
- Mild soreness at injection site
- Low-grade fever
- Decreased appetite
Call your vet immediately if you see symptoms of an allergic reaction (Anaphylaxis), typically within minutes to hours of the shot:
- Swelling of the face, muzzle, or eyes
- Hives or bumps on the body
- Vomiting or diarrhea
- Difficulty breathing / Collapse
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